Research
Neural correlates underling placebo response
(Yasushi Kishimoto)
Placebo response refers to a physiological phenomenon in which various symptoms are alleviated by an inert substance in a narrow sense. This phenomenon has been empirically used in medicine since ancient times, but has not been on the verge of natural science research for a long time. Although psychological research suggests that "expectation", "context" or "conditioning" plays an important role, the molecular mechanism in the brain is not clear. For this elucidation, research on experimental animals is important, but there are few situations in the world. The purpose of this study is to clarify the synaptic and molecular mechanisms in the brain of the placebo reaction by applying various neuroscience methodologies such as behavioral science, pharmacology, and electrophysiology to mice.
Theme 2. Molecular and synaptic mechanisms underlying discrete motor learning.
(Yasushi Kishimoto)
The aims of the study were two-fold: (1) to examine the role of unknown functional gene in cerebellum-dependent motor learning and (2) to clarify the molecular and synaptic mechanisms underlying eyeblink conditioning. We have found a lot of functional genes involved in the learning (e.g. GluRδ2, GluRε1, cannabinoid receptor CB1, PLCβ4, mGluR1). We have also identified the cellular and synaptic mechanisms underlying acquisition, expression and storing in the motor memory process by using cell-type-specific reversible control of gene expression.

Grant Support: Grants from Ministry of Education, Culture, Sports, Science and Technology of Japan.

Major Publication: PLoS ONE (2015), J Neurosci (2014), J Neurosci (2011), PNAS (2007), EMBO J (2007), J Neurosci (2006), J Neurosci (2006)
Theme 2. Comprehensive behavioral test battery of neurodegenerative disease mouse models
(Yasushi Kishimoto)
We are attempting to clarify the onset mechanisms of neurodegenerative disease and to find a treatment to decrease the cognitive impairments. We have recently shown that trace eyeblink conditioning and water-finding test are more susceptible to age-related cognitive deterioration in Tg2576 mice than the Morris water maze (MWM) task. The water-finding test has been described as a latent memory and learning paradigm that is related to the attention process and the ability to sort visuospatial information We propose that the water-finding test and trace eyeblink conditioning are a rapid and sensitive methods that can be used to assess cognitive and/or behavioral deficits in mouse models of Alzheimer's disease.

Grant Support: Grants from Ministry of Education, Culture, Sports, Science and Technology of Japan, and the Takeda Science Foundation

Major Publication:Cell Reports (2017), Neuron (2016), Front Behav Neurosci (2015), PLoS ONE (2013), J Neurosci (2011)
Quantitative and quantitative evaluation of pharmacology research and pharmacist education by shifting to six-year pharmacy education
(Yasushi Kishimoto)
Pharmaceutical Faculty Department of Pharmaceutical Sciences ten years have passed since the start of education, and during this time, education surrounding undergraduates the research environment has undergone a big change as well as internal and external change such as increase of the pharmacy department itself and decrease of 18 years old population It can be said. Evaluating this evaluation quantitatively at the present time can be a guide for future pharmacy education. In this laboratory, we analyze and evaluate the research productivity etc. of faculty members of the faculty of medicine over the past 20 years using methods such as multivariate analysis.