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Tokushima Bunri University
Kagawa School of Pharmaceutical Sciences

Publications, Awards & Grants   

Papers
Books
Reviews in Japanese
Invited Lectures & Lectures at Symposia

Awards
Grants

                                                                                                                                                                                                           
Papers


Okayasu, I., Hana, K., Nemoto, N., Yoshida, T., Saegusa, M., Yokota-Nakatsuma, A., Song, S.-Y., and Iwata, M.: Vitamin A inhibits development of dextran sulfate sodium-induced colitis and colon cancer in a mouse model. BioMed Res Int: Article ID 4874809 (2016).



Ohoka, Y
, Yokota-Nakatsuma, A, Maeda, N, Takeuchi, H, and Iwata, M.: Retinoic Acid and GM-CSF Coordinately Induce Retinal Dehydrogenase 2 (RALDH2) Expression through Cooperation between the RAR/RXR Complex and Sp1 in Dendritic Cells. PLoS One. 9(5): e96512 (2014).


Yokota-Nakatsuma, A., Takeuchi, H., Ohoka, Y., Kato, C., Song, S.-Y., Hoshino, T., Yagita, H., Ohteki, T., and Iwata, M.: Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol 7(4):786-801 (2014). Epub 2013 Nov 13.


Takeuchi, H., Yokota-Nakatsuma, Y., Ohoka, Y., Kagechika, H., Kato, C., Song, S.-Y., and Iwata, M.: Retinoid X receptor agonists modulate Foxp3+ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation. J Immunol 191(7):3725-3733 (2013). Epub 2013 Aug 26.


Sato, T., Kitawaki, T., Fujita, H., Iwata, M., Iyoda, T., Inaba, K., Ohteki, T., Hasegawa, S., Kawada, K., Sakai, Y., Ikeuchi, H., Nakase, H., Niwa, A., Takaori-Kondo, A., and Kadowaki, N.: Human CD1c+ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D3. J Immunol 191(6):3152-3160. Epub 2013 Aug 21.


Chaya T., Shibata S., Tokuhara Y., Yamaguchi W., Matsumoto H., Kawahara I., Kogo M.,
Ohoka Y., and Inagaki S.: Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).
J Biol Chem 286: 29511- 29520 (2011). Epub 2011 Jun 30. 

Tezuka, H., Abe, Y., Asano, J., Sato, T., Liu, J., Iwata, M., and Ohteki, T.

Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity  34(2): 247-257 (2011). Epub 2011 Feb 17.


Takeuchi, H., Yokota, A.,  Ohoka, Y., and Iwata, M.: CYP26B1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β. PLoS ONE 6(1): e16089 (2011).


Ohoka, Y., Yokota, A., Takeuchi, H., Maeda, N., and Iwata, M.:
Retinoic acid-induced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complex.
J Immunol 186:733-744 (2011). Epub 2010 Dec 8.


Takeuchi, H., Yokota, A.,  Ohoka, Y.Kagechika, H., Kato, C., Song, S.-Y., and Iwata, M.:

Efficient induction of CCR9 on T cells requires co-activation of retinoic acid receptors and retinoid X receptors (RXR): Exaggerated T cell homing to the intestine by RXR activation with organotins. J Immunol 185: 5289-5299 (2010). Epub 2010 Sep 29.


Chang, S.-Y., Cha, H.-R., Chang, J.-H., Ko, H.-J., Yang, H., Malissen, B., Iwata, M.  Kweon, M.-N.:
Lack of retinoic acid leads to increased langerin-expressing dendritic cells in gut-associated lymphoid tissues.
Gastroenterology 138(4): 1468-78 (2010). Epub 2009 Nov 13.

Yokota,A.
Takeuchi, H.Maeda, N.Ohoka, Y., Kato, C., Song, S.-Y., and Iwata, M.:
GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity.
International Immunology 21(4): 361-377 (2009). Epub 2009 Feb 3.
(This paper was selected as the Featured Article of The Month in the journal)


Iwata, M.: Retinoic acid production by intestinal dendritic cells and its role in T-cell trafficking. 
Seminar Immunol 21(1): 8-13 (2009). Epub 2008 Oct 11.

Iwata*, M.:
The roles of retinoic acid in lymphocyte differentiation. Seminar Immunol 21(1): 1 (2009). Epub 2008 Oct 5. (Editor's Summary).
(* Iwata served as The Guest Editor of this issue entitled above.)

Korostylev, A., Worzfeld, T., Deng, S., Friedel, RH., Swiercz, JM., Vodrazka, P., Maier, V., Hirschberg, A., Ohoka, Y., Inagaki, S., Offermanns, S., Kuner, R.: A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis.
Development 135(20): 3333-43 (2008). Epub 2008 Sep 17.                                                                                                                                                                                                                                                                                                      
Mora, J. R., Iwata, M., von Andrian, U.H.: Vitamin effects on the immune system: vitamins A and D take centre stage. Nature Rev Immunol  8: 685-698 (2008).

Tezuka, H., Abe, Y., Iwata, M., Takeuchi, H., Ishikawa, H., Shiohara, T., Akira, S., and Ohteki, T.: Regulation of IgA production by naturall occurringTNF/iNOS-producing dendritic cells. Nature 448: 929-933 (2007).
 
Takeuchi, H., Georgiev, O., Fetchko, M., Kappeler, M., Schaffner, W., and Egli, D.: In vivo construction of transgenes in Drosophila. Genetics 175: 2019-2028 (2007).

Mora*, J. R., Iwata*, M., Eksteen*, B., Song, S.-Y., Junt, T., Senman, B., Otipoby, K. L., Yokota, A., Takeuchi, H.: Ricciardi-Castagnoli, P., Rajewsky, K., Adams, D. H., von Andrian, U. H.: Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science  314: 1157-1160 (2006).
(*These authors contributed equally to this work.)
 
Iwata, M. : Role of Vitamin A in T Cell Homing to the Gut.
Curr Immun Rev 2: 345-355 (2006).

Yamada, T., Ohoka, Y., Kogo, M., Inagaki, S.: Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing RhoGEFs.
J Biol Chem 280: 19358-19363 (2005).

Takeuchi, H., Rigden, D. J., Ebrahimi, B., Turner, P. C., and Rees, H. H.: Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration. Biochem J 389: 637-645 (2005).

Yokota, A., Takeuchi, E., Iizuka, M., Ikegami, Y., Takayama, H., Shinohara, N.: Prominent dominant negative effect of a mutant Fas molecule lacking death domain on cell-mediated induction of apoptosis.
Mol Immunol 42: 71-78 (2005).

Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C., and Song, S.-Y.: Retinoic acid imprints gut-homing specificity on T cells.
Immunity 21:527-538 (2004).
(Selected articles that introduce the above paper:
Immunity 21:458-460 (2004). Preview. Retinoic acid: An educational "vitamin elixir" for gut-seeking T cells. by Mora, JR., and von Andrian, U.H.; Nature Medicine 10: 1300-1301 (2004). News & Views. Vitamin A helps gut T cells find their way in the dark. by Johansson-Lindbom, B., and Agace, WW.; Science STKE 2004(256):tw380 (2004). Editor’s Choice. Going for the gut. by Wilson JDK.)

Iwata, M.
, Eshima, Y., Kagechika, H., and Miyaura, H.: The endocrine disruptors nonylphenol and octylphenol exert direct effects on T cells to suppress Th1 development and enhance Th2 development.
Immunol Lett 94: 135-139 (2004).
 
Lai, R., Takeuchi, H., Jonczy, J., Rees, H. H., and Turner, P. C.: A thrombin inhibitor from the ixodid tick, Amblyomma hebraeum.
Gene 342: 243-249 (2004).

Takeuchi, H., Chen, J. H., Jenkins, J. R., Bun-Ya, M., Turner, P. C., and Rees, H. H.: Characterization of a sterol carrier protein 2/3-oxoacyl-CoA thiolase from the cotton leafworm (Spodoptera littoralis): a lepidopteran mechanism closer to that in mammals than that in dipterans.
Biochem J 382: 93-100 (2004).

Lai, R., Takeuchi, H., Lomas, L. O., Jonczy, J., Rigden, D. J., Rees, H. H., and Turner, P. C.: A new type of antimicrobial protein with multiple histidines from the hard tick, Amblyomma hebraeum.
Faseb J 18: 1447-1449 (2004).

Iwata, M., Eshima, Y., and Kagechika, H.: Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.
Int Immunol 15: 1017-1025 (2003).
 
Tosa, N., Murakami, M., Jia, W.Y., Yokoyama, M., Masunaga, T., Iwabuchi, C., Inobe, M., Miyazaki, T., Onoe, K., Iwata, M., and Uede, T.: Critical function of T cell death-associated gene 8 (TDAG8) in glucocorticoid-induced thymocyte apoptosis. Int Immunol 15: 741-749 (2003).
 
Tani, N., Higashiyama, S., Kawaguchi, N., Madarame, J., Ota, I., Ohoka, Y., Shiosaka, S., Takada, Y., Matsuura, N.: Expression level of integrin alpha 5 on tumour cells affects the rate of metastasis to the kidney.
Br J Cancer 88: 327-333 (2003).

Fujioka, S., Masuda, K., Toguchi, M., Ohoka, Y., Furuyama, T., Inagaki, S.: Neurotrophic effect of Semaphorin 4D in PC12 cells.
Biochem Biophys Res Commun 301: 304-310 (2003).

Yokota, A., Oikawa, A., Matsuda, C., Shinohara, N., Eshima, K.: Cell-mediated Fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody.
Microbiol Immunol 47: 285-93 (2003).

Tsukumo, S., Iwata, M., Tohyama, C., and Nohara, K.: Skewed differentiation of thymocytes toward CD8 T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires activation of the extracellular signal-related kinase pathway.
Arch Toxicol 76: 335-343 (2002).
 
Adachi, S., and Iwata, M.: Duration of calcineurin signal and ERK signal regulates CD4/CD8 lineage commitment of thymocytes.
Cell Immunol 215:45-53 (2002).
 
Amasaki, Y., Adachi, S., Ishida, Y., Iwata, M., Arai, N., Arai, K, and Miyatake, S.: Constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4+CD8+ T cells.
J Biol Chem 277: 25640-25648 (2002).
 
Miyaura, H., and Iwata, M.: Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids.
J Immunol 168: 1087-1094 (2002).
 
Hirotani, M., Ohoka, Y., Yamamoto, T., Nirasawa, H., Furuyama, T., Kogo, M., Matsuya, T., Inagaki, S.: Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors. 
Biochem Biophys Res Commun 297: 32-37 (2002).

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Books

Mora, J.R. and Iwata, M.: Retinoids and the Immune System. In The Retinoids: Biology, Biochemistry, and Disease, Chapter 21, P. Dolle, K. Niederreither, ed. Wiley, p.465-483 (2015).


Iwata, M., and Yokota, A.: Retinoic acid production by intestinal dendritic cells. In Vitamins & Hormones, Volume 86, “Vitamins and The Immune System” Chapter Six, G. Litwack, ed.  Elsevier, p.127-152.(2011).


Iwata, M.: Involvement of retinoic acid: Dynamic cell trafficking in mucosal immunity. In Clinical Mucosal Immunology, H, Kiyono, ed. (Tokyo, Japan, Synergy), pp. 227-235. (2010). (In Japanese)

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Reviews in Japanese


Iwata, M.: Essential roles of vitamin A in immunological homeostasis. Journal of Kagawa Prefecture Pharmacists Association “Kagayaku” 153: 49-50 (2014).


Iwata, M.: Retinoic acid-producing dendritic cells and their functions.

Clinical Immunology & Allergology (Rinsho Men-eki Allergy-ka) 62(6): 588-592, (2014).


Yokota-Nakatsuma, A. and Iwata, M.: Regulation of inflammatory dendritic cells by vitamin A. Inflammation & Immunity (Ensho-to-Men-eki) 22 (4): 63(295)-67(299) (2014).


Iwata, M.: Regulation of Treg differentiation and function by retinoic acid.

Journal  of  Clinical and Experimental Medicine (Igaku No Ayumi) 

246 (10): 857-863 (2013).

 

Yokota-Nakatsuma, A.: Regulation of retinoic acid-producing ability in dendritic cells.

Clinical Immunology & Allergology (Rinsho Men-eki Allergy-ka) 59 (3): 392-397 (2013).

 

Iwata, M.: Lymphocyte homing and inflammatory bowel diseases.

J Gastrointest Res (G.I. Research) 20 (6): 41(493)-45(497) (2012).

 

Yokota-Nakatsuma, A.: Vitamin A status influences functional differentiation of T cells through affecting the function of intestinal dendritic cells. Clinical Immunology & Allergology (Rinsho Men-eki Allergy-ka) 57 (1): 8-13 (2012).


Iwata, M.: Molecular mechanisms to determine the tissue tropism of lymphocytes.

Japanese Journal of Lymphology 34 (2): 112-116 (2011).


Iwata, M.: Small intestine-specific lymphocyte homing. Surgery Frontier
18 (4): 68(402)-71(405) (2011).


Iwata, M.: Tissue-specific lymphocyte homing. Inflammation & Immunity 

(Ensho-to-Men-eki) 19 (5): 2(444)-7(449) (2011).


Yokota, A.: Regulation of lymphocyte trafficking by retinoic acid-producing dendritic cells in the intestine. Clinical Immunology & Allergology (Rinsho Men-eki Allergy-ka)
55 (4): 454-459 (2011).


Takeuchi, H., Ohoka, Y., and Iwata, M.: The molecular mechanism of acquisition of gut tropism by lymphocytes. Saibou Kougaku (Cell Technology) 30(4): 381-386 (2011).


Yokota, A., Iwata, M.: Factors responsible for retinoic acid- producing ability in intestinal dendritic cells. Clinical Immunology & Allergology (Rinsho Men-eki Allergy-ka)
54 (4): 492-498 (2010).

Iwata, M.: Dendritic cell functions and their regulation in mucosal tissues. Inflammation & Immunity (Ensho-to-Men-eki) 18 (5): 14(474)-18(478) (2010).


Yokota, A., Iwata, M.: Vitamins and Immunity - focusing on vitamin A. Functional Food 4 (1): 61-65 (2010).

Iwata, M.: Role of retinoic acid in the gut mucosal immunity.
Kagaku to Seibutsu (Chemistry and Biology) (Japan Society for Bioscience, Biotechnology, and Agrochemistry) 48 (6): 389-394 (2010).

Iwata, M.: Regulation of immune functions by retinoic acid.
Journal of Kagawa Prefecture Pharmacists Association “Kagayaku”134: 58-59 (2009).

Iwata, M.: Regulation of lymphocyte homing and differentiaton by vitamin A. Vitamins (Japan).  83(8): 441-452 (2009).

Iwata, M.: Tissue-specific lymphocyte homing. Encyclopedia of Inflammation & Regenerative Medicine. 195-197 (2009).


Iwata, M.: Importance of vitamin A in lymphocyte differentiation and distribution in the gut. Japanese Journal of Lymphology  31(2) : 33-37 (2008).


Iwata, M.: The role of vitamin A in gut immunity.
Japanese Journal of Nutritional Assessment25: 59-62 (2008).


Iwata, M.: Deployment and functional regulation of lymphocytes in the gut by vitamin A. Experimental Medicine (Jikken Igaku) Extra Edition.
25 (20):142(3220)-146(3224)(2007).

Iwata, M.: Regulation of lymphocyte trafficking by retinoids. Annual Review Immunology 2008. 154-161 (2007).

Iwata, M.: Role of vitamin A in the gut immunity. Journal of Intestinal Microbiology. 21: 297-304 (2007).

Iwata, M.: Regulation of gut-specific lymphocyte homing by retinoic acids. Experimental Medicine (Jikken Igaku) Extra Edition, Frontiers of Immunological Research 2007.  24: 3253-3259 (2006).

Iwata, M.: Vitamin A is essential for the gut immunity. Journal of Clinical and Experimental Medicine (Igaku No Ayumi).  219 (10): 795-796 (2006).

Iwata, M.: Role and Mechanism of Action of Vitamin A in Gut Immunity.
Seikagaku.  78(8): 738-748.

Iwata, M.: Role of vitamin A in immune surveillance: Regulation of lymphocyte homing. Infection Inflammation Immunity (Kansen Ensho Men-eki). 36: 22-32 (2006).

Iwata, M.: Regulation of lymphocyte homing by retinoic acid. Molecular Medicine Extra Edition Immunity 2006. 42: 22-28 (2005).
 
Iwata, M.: Induction of T cell homing to the gut with retinoic acid. Clinical Immunology (Rinsho Men-eki). 44: 299-301 (2005).
 
Iwata, M.: Regulatory mechanism of gut tissue-specific T cell homing.
Pharmacia.
 41 (6): 513-517 (2005).
 
Iwata, M.: Suppression of Th1 development by retinoic acid. Clinical Immunology (Rinsho Men-eki).  41 (5): 520-526 (2004).
 
Iwata, M.: Signal transduction for apoptosis. Japanese Journal of Pediatric Medicine.
 34 (12): 1731-1735 (2002).

Yokota, A.: Elimination of antigen-presenting cells by CD4+ cytotoxic T lymphocytes. Clinical Immunology (Rinsho Men-eki).  38 (suppl.20): 209-214 (2002)


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Invited Lectures & Lectures at Symposia


Iwata, M.  “Development and functional regulation of the intestinal immune system”

at The 52rd Annual Meeting of Japanese Society of Pediatric Allergy and Clinical Immunology, Nara, Japan, November 21, 2015.


Iwata, M.  “The role of retinoic acid in immune functions”

at The 3rd International Conference on Retinoids (26th Congress of the Japanese Society for Retinoid Research), Gifu, Japan, October 22, 2015.


Iwata, M.  “The role of retinoic acid in immune functions”

at Academy of Immunology and Microbiology (AIM), The Institute for Basic Science (IBS) in Pohang University of Science and Technology (POSTECH) (Director, Prof. Surh), Pohang, Korea, May 27, 2015.


Iwata, M. “Regulation of immune inflammatory responses by retinoid signals”

The 135 Annual Meeting of The Pharmaceutical Society of Japan, Symposium “Environmental Regulation of Inflammatory Responses”, Kobe Gakuin University, Hyougo, March 26, 2015.


Yokota-Nakatsuma, A. "Regulation of intestinal immune responses by vitamin A"

Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry 2014 Kanagawa, March 30, 2014.


Iwata, M. "Vitamin A regulates immunity"
Japanese Association for Food Immunology Award Lecture

The 9th Annual Meeting of Japanese Association for Food Immunology (JAFI 2013), Ito International Research Center, University of Tokyo, Tokyo, October 18, 2013.


Iwata M. "Regulation of immune responses to foods by vitamin A and its disruption"

The 6th Symposium of Japanese Association for Food Immunology (JAFI), Tokyo, Jun 21, 2013.


Iwata M. "The intestine and immunity"

The 43th Janan Pharmaceutical Library Association Kinki-ChuShikoku-Kyushu Region Meeting Lecture, Kagawa, May 17, 2013.


Iwata M. "Regulation of immune responses by retinoic acid-producing dendritic cells"

The 9th Gastroenterological Surgery Conference Kanazawa University, Kanazawa, Apr 22, 2013.


Iwata, M. The role of vitamin A that regulates immunity ifia/HFEE JAPAN 2012 (The 17th International Food Ingredients & Additives Exhibition and Conference/The 10th Health Food Exposition & Conference), Tokyo International Exhibition Center Tokyo Big Sight, Tokyo, May 24, 2012.


Iwata, M. The role of retinoic acid signals in immune functions”

International Symposium “New Horizons in The Immune System”- A Strategic Project for Innovative Research, University of Tokushima, Tokushima, February 9-10, 2012.


Iwata, M. Regulation of homing and differentiation of T cells by gut dendritic cells ---- The role of retinoic acid signals

The 32nd Institute of Natural Medicine Special Seminar - Mucosal Immune System as A Target of Natural Medicine, Insitute of Natural Medicine, University of Toyama, Toyama-kenminkaikan, Toyama, Dec 9, 2011.


Iwata, M.  Molecular mechanisms of tissue-selective lymphocyte trafficking
The 35th Annual Meeting of the Japanese Society of Lymphology, Tokyo Station Conference, Tokyo, June 3, 2011.


Iwata, M.  Vitamin A supplementation saves children's lives

Seminar at Faculty of Nutritional Science (Prof. Tatsumi), Sagami Women's University, Kanagawa, January 23, 2010.


Iwata, M.   “Vitamin A is required for gut immunity”
Kagawa Consortium for Multidisciplinary Madical Education and Research Academic exchange meeting of the three universities
(Tokushima Bunri University, Kagawa University School of Medicine, Kagawa Prefectural College of Health Sciences), Kagawa,
Dec 17, 2009.

Yokota, A.
Regulation of lymphocyte homing and differentiation by retinoic acid-producing dendritic cells in the intestine
The 39th Annual Meeting of the Japanese Society for Immunology, Symposium Immune Cell Trafficking at Osaka, Dec 2, 2009.

Iwata, M.   “Regulation of  immune functions by retinoic acid”
Institute of Health Biosciences The University of Tokushima Graduate School, Program for Enhancing Systematic Education in Graduate Schools,
Awaji, Nov 28, 2009.


Iwata, M.   “Regulation of  lymphocyte homing and functions by Vitamin A”
The 59th Annual Meeting of Japanese Society of Allergology, Akita, Oct 31, 2009.


Iwata, M.   “Regulation of functional differentiation and trafficking of lymphocytes by retinoic acid”
at Kagawa University School of Medicine (Prof. Hirashima), Miki-cho, Kita-gun, Kagawa, Sep 28, 2009.


Iwata, M.   “Regulation of immune function by vitamin A”
at Kagawa University School of Medicine (Prof. Hirashima), Miki-cho, Kita-gun, Kagawa, June 8, 2009.


Iwata, M.  
Regulation of immune functions by vitamin A
Japanese Association for Food Immunology (JAFI2009), The University of Tokyo, Tokyo, May 27,2009.

Iwata, M.  
Regulation of immunological functions by vitamin A
International Symposium 2009 - Nutritional, Medical and Social Sciences for Children Seirankodo, University of Tokushima, Tokushima, January 23, 2009.


Iwata, M.  
Regulation of gut immunity by retinoids
The 15th Annual Meeting of the Japanese Society of Immunotoxicology, Tower holl funabori, Tokyo, September 12, 2008.

Iwata, M.  Regulation of gut lymphocyte differentiation and localization by retinoic acid
Gut Immunity Conference, Pharmacology Research Laboratories I, Takeda Pharmaceutical Company, Osaka, August 1, 2008.

Iwata, M.  
Regulation of lymphocyte homing and functions by retinoic acid
320th Lipophilic Vitamins Research Conference, Osaka Medical College, Takatsuki, Osaka, July 18, 2008.

Iwata, M.  Vitamin A plays critical roles in the differentiation and localization of lymphocytes in the intestine32th Annual Meeting of The Japanese Society of Lymphology, Chiyoda-ku, Tokyo, June 6, 2008.

Iwata, M.  Regulation of  lymphocyte homing and functions by retinoic acid
118th The Chu-Shikoku Branch Meeting of The Pharmaceutical Society of Japan Lecture, Kagawa, January 26, 2008.

Iwata, M.  Regulation of  lymphocyte homing and differentiation by retinoic acid
at  Tokushima University Faculty of Medicine, Graduate School of Medical Sciences (Prof. Takahama),Tokushima, November 30, 2007.


Iwata, M.  Regulation of gut-specific lymphocyte homing by retinoic acid”  
The 4th Meet The Expert, Department of Hematology and Oncology, Nagoya University Graduate School Of Medicine, Nagoya, Aichi, November 26, 2007.

Iwata, M.  Regulation of lymphocyte homing by retinoids
The Korean Association of Immunobiologists, 55th Fall Conference, JW Marriott Hotel, Seoul, Korea, November 9, 2007.


Iwata, M.  “Role of vitamin A in Lymphocyte Homing to The Gut”  
13th International Congress of Mucosal Immunology (ICMI2007)/ Japanese Association for Food Immunology (JAFI), Joint Meeting, Shinagawa, Tokyo,
July 11, 2007.


Iwata, M.  “Regulaory mechanism of lmphocyte homing specificity”
  251thChiba Bioscience Seminar, Chiba University Graduate Scool of Medicine (Prof. Nakayama), Chiba-shi, Chiba, June 1, 2007. 


Iwata, M.  “Role of vitamin A in the gut immunity”  

at Tottori University Faculty of Medicine, School of Life Science (Prof. Hayashi), Yonago-shi, Tottori, January 16, 2007
.

Iwata, M.  
Regulation of lymphocyte trafficking by retinoids
The 36th Annual Meeting of the Japanese Society for Immunology, Symposium Cell movement and trafficking at Osaka, December 11, 2006.


Iwata, M.  Regulation of lymphocyte homing by retinoids
MBSJ (The Molecular Biology Society of Japan) Forum 2006 Molecular Biology - the Next Decade, Symposium Spatiotemporal regulation of blood cell behavior during hematopoiesis and immune response, in Nagoya, Aichi, December 6, 2006.

Iwata, M.  “Regulation of lymphocyte homing by retinoids”
The 10th GI Cell Biology Meeting
, in Iidabashi, Chiyoda-ku, June 20, 2006.


Iwata, M.   “Regulation of lymphocyte homing by vitamin A”
at Kagawa University School of Medicine (Prof. Hirashima), Miki-cho, Kita-gun, Kagawa, June 6, 2006.


Iwata, M. “The role of dendritic cells and retinoids in regulating lymphocyte trafficking”
2006 BMT (The American Society for Blood and Marrow Transplantation) Tandem Meetings, Plenary Session “Cell Trafficking and Homing”, in Honolulu, Hawaii, February 16-20, 2006.


Iwata, M. “Regulation of lymphocyte homing by retinoids”
Age Dimension Research Center (ADRC) Symposium “Homeostasis and Immunity”, at National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, January 27, 2006.


Iwata, M. “Effects of environmental chemicals on T lymphocyte functional differentiation”
Japanese Society for Molecular Preventive and Environmental Medicine, The 5th Annual Meeting, Symposium “Effects of Environmental Chemicals on Health”, Hongo, Bunkyo-ku, Tokyo, November 25-26, 2005.


Iwata, M. “Regulation of lymphocyte homing by retinoids”
Japanese Society for Retinoid Research The 16th Symposium of Retinoids “Retinoids and Immune Functions”, Hongo, Bunkyo-ku, Tokyo, November 10-11, 2005.


Iwata, M. “The role of retinoids regulating lymphocyte trafficking”
at Medizinishe Hochschule Hannover (Prof. Forster), Hannover, Germany, October 19, 2005.

Iwata, M. “The role of retinoids regulating lymphocyte trafficking”
at Charite-Universitaetsmedizin Berlin, Medizinische Klinik mit Scherpunkt, Rheumatologie und klinche Immunologie (Prof. Hamann), Berlin, Germany, October 18, 2005.


Iwata, M.  “Role of vitamin A in the gut immunity”
Tokushima Prefecture High School Education, Science Education Meeting, Tokushima, August 25, 2005.


Iwata, M. “Role of vitamin A in the gut immunity” 
Japanese Association of Animal Cell Technology 2005 Annual Meeting (JAACT2005),
Symposium“Regulation by the gut immunity and food”
(co-organized by JAACT and Japanese Association for Food Immunology),Hongo, Bunkyo-ku, Tokyo, July 6-7, 2005.


Iwata, M. “Role of vitamin A in the imprinting of gut-homing T cells”
The 14th International Symposium on Molecular Cell Biology of Macrophages 2005,  Omiya, Saitama, Japan, June 3-4, 2005.


Iwata, M. “Retinoic acid imprints gut-homing specificity on T cells”
Keystone Symposia
, Leukocyte Trafficking: Cellular and Molecular Mechanisms
,  Taos, New Mexico, USA, March 1-6, 2005.

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Awards

Japanese Association for Food Immunology Award, Makoto Iwata (October 18, 2013)

The 9th Japanese Association for Food Immunology meetihg, Poster Award,
Aya Yokota-Nakatsuma (October 18, 2013)


Grants

Grant-in-Aid for Scientific Research on Priority Areas from the Japanese Ministry of Education, Culture, Sports, Science and Technology (2005-2006),  Makoto Iwata.

Grant-in-Aid for Scientific Research (B) from Japan Society for the Promotion of Science (2005-2007),  Makoto Iwata.


Long-range Research Initiative (LRI) grant from Japan Chemical Industry Association (2006-2007),  Makoto Iwata.  

The Naito Foundation
grant (2006-2007),  Makoto Iwata.

Grant-in-Aid for Exploratory Research from Japan Society for the Promotion of Science (2007-2008),  Makoto Iwata.

Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science (2007-2009),  Hajime Takeuchi.

Grant-in-Aid for Young Scientists (B) from the Japanese Ministry of Education, Culture, Sports and Technology  (2007-2008),  Aya Yokota.

Grant from The SKYLARK Food Science Institute (2007-2008),  Hajime Takeuchi.


Long-range Research Initiative (LRI) grant from Japan Chemical Industry Association (2007-2008),  Makoto Iwata.

The Uehara Memorial Foundation grant (2008-2009),  Makoto Iwata.

Grant-in-Aid for Scientific Research on Priority Areas from the Japanese Ministry of Education, Culture, Sports, Science and Technology (2008-2009),  Makoto Iwata.

Long-range Research Initiative (LRI) grant from Japan Chemical Industry Association (2008-2009),  Makoto Iwata.

JST (CREST) (2008-2013), Makoto Iwata.

Grant from Research Foundation ITSUU Laboratory (2009-2010), Hajime Takeuchi.

Grant-in-Aid for Young Scientists (B) from the Japanese Ministry of Education, Culture, Sports and Technology  (2009-2010),  Aya Yokota.

The Danone Institute of Japan Research Grant (2010), Makoto Iwata.

Grant-in-Aid for Scientific Research on Priority Areas from the Japanese Ministry of Education, Culture, Sports, Science and Technology (2010-2011),  Makoto Iwata.


Grant-in-Aid for Scientific Research (B) from Japan Society for the Promotion of Science (2011-2013),  Makoto Iwata.

Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science (2011-2013),  Hajime Takeuchi.

Grant-in-Aid for Young Scientists (B) from the Japanese Ministry of Education, Culture, Sports and Technology  (2011-2012),  Aya Nakatsuma.

Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science (2012-2014),  Yoshiharu Ohoka.

The Uehara Memorial Foundation grant (2013-2014),  Makoto Iwata.

Grant-in-Aid for Scientific Research on Innovative Areas from the Japanese Ministry of Education, Culture, Sports, Science and Technology (2013-2014),  Makoto Iwata.

Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science (2013-2015),  Aya Nakatsuma.

Grant-in-Aid for Scientific Research (B) from Japan Society for the Promotion of Science (2014-2016),  Makoto Iwata.

Takeda Science Foundation (2014-2017), Aya Nakatsuma.

Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science (2015-2017),  Yoshiharu Ohoka.

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