| 教 授 | 加藤 善久 博士(薬学) | Yoshihisa KATO, Ph.D. |
| 講 師 | 榊原 紀和 博士（薬学） | Norikazu SAKAKIBARA, Ph.D. |
| 助 教 | 跡部 一孝 博士(薬学) | Kazutaka Atobe, Ph.D. |
これまで、薬物動態学、薬物代謝学を研究基盤として、外来異物、特に有機塩素系化合物の代謝、薬物代謝酵素誘導作用、血中甲状腺ホルモン濃度低下作用メカニズムに関する生物薬剤学的研究に取り組んできました。生物薬剤学、薬物動態学は薬物の生体内動態を研究対象としているため、薬物が生体に投与された後にたどる吸収、分布、代謝、排泄の過程を生理学的、生化学的、物理化学的にとらえる知識が要求されます。この薬物の体内動態に関する知識は、適切な薬物の投与設計を行う上でも重要であるために、薬物動態学は臨床薬剤学とも密接に関係しています。それゆえに、薬物代謝学を中心にして、薬物動態と薬効、毒性の関係を解明することで、有効性や安全性の科学的な評価による創薬と最適な薬物療法の構築に関する研究を積極的に推進していきたいと考えております。
香川薬学部薬学科を卒業した者は、すべて薬剤師免許を取得し、薬学のプロフェッショナルとして、医療の現場で活躍することが期待されます。そこで、我々教員の使命は、個体レベルから分子レベル、遺伝子レベルに関する疾病の予防、保健衛生、薬物治療に関する広範囲な専門的知識を身につけ、それらを総合的に活用し、自立して、公衆衛生ならびに医療活動を遂行できる薬剤師を育成すること、また快適な地域医療環境の創造と整備を推し進め、健康の維持、増進に役立つ高度な専門技術を身につけた薬剤師を養成することであると考えております。
とりわけ、臨床の現場において柔軟性を持ちチーム医療や地域医療に参画できる薬剤師、技術の習得だけではなく自らコンセプトを樹立することのできる薬剤師を教育することが重要であると考えております。さらに、社会のニーズに答え、狭い医療薬学の専門分野に留まることなく、生命科学、情報科学、環境科学のいずれにも強い薬剤師、よりグローバルな観点から国際社会で自分の意見を述べられる薬剤師の養成を目指したいと考えております。
香川薬学部を卒業した者は、自ら目標を立て、自ら日々精進し、薬剤師として自分を育てていける薬剤師であり、その卵を教え育てたいと考えています。また、常に自己努力、自己研鑽を重ね、社会が要求する薬剤師を、香川薬学部出身の薬剤師がブランドとなる薬剤師を育てるよう、また共に育つよう学生と接したいと考えております。また、医療に携わる者としての倫理感、人間の生命の根幹に関わる職務に従事するという自覚を身につけさせたいと考えております。
さらに、香川県民、さぬき市民の疾病の予防や健康に対する意識の高揚と啓発にも力を注ぎ、地域住民の健康の維持、増進に対しても積極的に取り組み、地域に溶け込み、根づき、受け入れられる香川薬学部に発展させていきたいと考えております。
日本トキシコロジー学会、日本薬物動態学会、日本薬学会、日本薬剤学会、日本内分泌撹乱化学物質学会、日本衛生学会、HAB研究機構
2014
Yoshihisa Kato, Koichi Haraguchi, Mao Onishi, Shinichi Ikushiro, Tetsuya Endo, Chiho Ohta, Nobuyuki Koga, Shizuo Yamada, and Masakuni Degawa: 3,3',4,4'-Tetrachlorobiphenyl-Mediated Decrease of Serum Thyroxine Level in C57BL/6 and DBA/2 Mice Occurs Mainly through Enhanced Accumulation of Thyroxine in the Liver. Biol. Pharm. Bull., (2014) 37, 504-509.
Yukiko Fujii, Eri Nishimura, Yoshihisa Kato, Kouji H. Harada, Akio Koizumi, and Koichi Haraguchi: Dietary exposure to phenolic and methoxylated organohalogen contaminants in relation to their concentrations in breast milk and serum in Japan. Environ. Int., (2014) 63, 19-25.
Futoshi Matsubara, Yasuko Sagara, Yoshihisa Kato, Kouji Harada, Akio Koizumi, and Koichi Haraguchi: Detection of Antibodies to Human T-Cell Leukemia Virus Types 1 and 2 in Breast Milk from East Asian Women. Biol. Pharm. Bull., (2014) 37, 311-314.
Osamu Kimura, Chiho Ohta, Nobuyuki Koga, Koichi Haraguchi, Yoshihisa Kato, and Tetsuya Endo: Carrier-mediated uptake of Nobiletin, a citrus polymethoxyflavonoid, in human intestinal Caco-2 cells. Food Chemistry, (2014) 154, 145-150.
2013
Yoshihisa Kato, Mao Onishi, Koichi Haraguchi, Shinichi Ikushiro, Chiho Ohta, Nobuyuki Koga, Tetsuya Endo, Shizuo Yamada, and Masakuni Degawa: A possible mechanism for 2,3',4,4',5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level in mice. Biol. Pharm. Bull., (2013) 36, 1594-1601.(Highlighted paper selected by Editor-in-Chief)
Noriaki Hidaka, Katsuya Suemaru, Yoshihisa Kato, and Hiroaki Araki: Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats. Epilepsy Research, (2013) 104, 181-185.
Tetsuya Endo, Yohsuke Hisamichi, Osamu Kimura, Hideki Ogasawara, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, and Koichi Haraguchi: Levels of Mercury in Muscle and Liver of Star-Spotted Dogfish (Mustelus manazo) from the Northern Region of Japan: A Comparison with Spiny Dogfish (Squalus acanthias). Arch. Environ. Contam. Toxicol., (2013) 64, 467-474.
Norikazu Sakakibara, Takayuki Hamasaki, Masanori Baba, Yosuke Demizu, Masaaki Kurihara, Kohji Irie, Masatoshi Iwai, Eriko Asada, Yoshihisa Kato, and Tokumi Maruyama: Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents. Bioorg. Med. Chem., (2013) 21, 5900-5906.
Norikazu Sakakibara, Ikuko Tsukamoto, Yohei Isono, Maki Takata, Ryoji Konishi, Yoshihisa Kato, and Tokumi Maruyama: A new method for synthesis and angiogenic evaluation of leteprinim potassium and its novel analogs. Heterocycles, (2013) 87, 2369-2384.
太田千穂、原口浩一、加藤善久、遠藤哲也、古賀信幸： 2,2',3,4',5,5'-六塩素化ビフェニル（CB146）のin vitro代謝の動物種差．福岡医学雑誌、(2013) 104, 161-169.
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Osamu Kimura, Nobuyuki Koga : In vitro metabolism of 2,2',4,4',5-pentachlorobiphenyl (CB99) by rat and guinea pig liver microsomes. Organohalogen Compounds, (2013) 75, 587-590.
榊原紀和、丸山徳見、加藤善久: 血管新生促進作用および抗HIV-1作用を有する新規核酸類縁体の創製. 香川県薬剤師会会誌 かがやく、(2013) 150, 68-70.
太田千穂、加藤善久、原口浩一、遠藤哲也、古賀信幸： ラットおよびモルモットの小腸と腎におけるノビレチンの代謝: 中村学園大学・中村学園大学短期大学部研究紀要、(2013) 45, 141-149.
2012
Yoshihisa Kato, Sekihiro Tamaki, Koichi Haraguchi, Shin-ichi Ikushiro, Masashi Sekimoto, Chiho Ohta, Tetsuya Endo, Nobuyuki Koga, Shizuo Yamada, and Masakuni Degawa: Comparative study on 2,2',4,5,5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level between C57BL/6 and its transthyretin-deficient mice. Toxicol. Appl. Pharmacol., 263, 323-329 (2012).
Yoshihisa Kato, Syohei Okada, Kazutaka Atobe, Tetsuya Endo, and Koichi Haraguchi: Selective determination of mono- and dihydroxylated analogs of polybrominated diphenyl ethers in marine sponges by liquid-chromatography tandem mass spectrometry. Anal. Bioanal. Chem., 404, 197-206 (2012).
Yoshihisa Kato, Sekihiro Tamaki, Koichi Haraguchi, Shin-ichi Ikushiro, Masashi Sekimoto, Chiho Ohta, Tetsuya Endo, Nobuyuki Koga, Shizuo Yamada, and Masakuni Degawa : 2,2',4,5,5'-Pentachlorobiphenyl-mediated inhibition of a serum T4-transthyretin complex formation is one of causes for the PCB-induced changes in the serum and hepatic T4 levels in mice. Organohalogen Compounds, 74, 1377-1380 (2012)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Nobuyuki Koga: Involvement of rat CYP3A enzymes in the metabolism of 2,2',3,4',5',6-hexachlorobiphenyl (CB149). Organohalogen Compounds, 74, 1475-1478 (2012)
太田千穂、原口浩一、遠藤哲也、加藤善久、松原 大、古賀信幸： 海洋生物由来の2,4,6-tribromoanisoleの動物肝ミクロゾームによる代謝とその関連化合物の抗酸化活性: 中村学園大学・中村学園大学短期大学部研究紀要、44, 215-224 (2012)
2011
Yoshihisa Kato, Mao Onishi, Koichi Haraguchi, Shinichi Ikushiro, Chiho Ohta, Nobuyuki Koga, Tetsuya Endo, Shizuo Yamada, and Masakuni Degawa: A possible mechanism for 2,2',4,4',5,5'-hexachlorobiphenyl-mediated decrease in serum thyroxine level in mice. Toxicol. Appl. Pharmacol., 254, 48-55 (2011)
Misaka Shingen, Kurosawa Souhei, Shinya Uchida, Yoshida Akira, Yoshihisa Kato, Yoshiyuki Kagawa, Shizuo Yamada: Evaluation of the pharmacokinetic interaction of midazolam with ursodeoxycholic acid, ketoconazole and dexamethasone by brain benzodiazepine receptor occupancy. J Pharm Pharmacol., 63, 58-64 (2011)
Nobuyuki Koga, Chiho Ohta, Yoshihisa Kato, Koichi Haraguchi, Tetsuya Endo, Kazunori Ogawa, Hideaki Ohta, and Masamichi Yano: In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450. Xenobiotica, 41, 927-933 (2011)
Koichi Haraguchi, Yoshihisa Kato, Chiho Ohta, Nobuyuki Koga, and Tetsuya Endo: Marine sponge: A potential source for methoxylated polybrominated diphenyl ethers in the Asia-Pacific food web. J. Agric. Food Chem., 59、13102-13109 (2011)
太田千穂、原口浩一、加藤善久、遠藤哲也、古賀信幸： 2,2',3,4,4',5'-六塩素化ビフェニル（CB138）のモルモットにおけるin vivo代謝．福岡医学雑誌、102、167-174(2011)
太田千穂、枩岡樹子、加藤善久、原口浩一、遠藤哲也、古賀信幸： フェニルプロパノイド類とフラボノイド類の抗酸化作用とα-グルコシダーゼ阻害作用：構造活性相関: 中村学園大学・中村学園大学短期大学部研究紀要、43、243-249(2011)
2010
Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Yoshiki Seto, Takashi Okura, Shin-ichi Ikushiro, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa: A possible mechanism for the decrease in serum thyroxine level by a 2,3,7,8-tetrachlorodibenzo-p-dioxin-like polychlorinated biphenyl congener, 3,3',4,4',5-pentachlorobiphenyl in mice. Drug Metab. Dispos., 38, 150-156 (2010)
Yoshihisa Kato, Koichi Haraguchi, Yuriko Ito, Aki Fujii, Tomoaki Yamazaki, Tetsuya Endo, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa: Polychlorinated biphenyl-mediated decrease in serum thyroxine level in rodents. Drug Metab. Dispos., 38, 697-704 (2010)
Yoshihisa Kato, Hiroshi Suzuki, Koichi Haraguchi, Shinichi Ikushiro, Yoshihiko Ito, Shinya Uchida, Shizuo Yamada and Masakuni Degawa: A possible mechanism for the decrease in serum thyroxine level by phenobarbital in rodents. Toxicol. Appl. Pharmacol., 249, 238-246 (2010)
Yoshihiko Ito, Taketsugu Harada, Kasumi Fushimi, Yoshiyuki Kagawa, Hidenobu Oka, Hiroshi Nakazawa, Reiko Homma, Yoshihisa Kato and Shizuo Yamada: Pharmacokinetic and pharmacodynamic analysis of acetylcholinesterase inhibition by distigmine bromide in rats. Drug Metab. Pharmacokinet., 25, 254-261 (2010)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Futoshi Matsubara and Nobuyuki Koga : Species difference in the in vitro metabolism of 2,2',3,4,4',5,5'-heptachlorobiphenyl (CB180). Organohalogen Compounds 72, 1796-1799 (2010)
加藤善久: 薬物の体内動態と薬効・毒性発現メカニズムの解明を目指して．薬剤学、70、303-308 (2010)
太田千穂、原口浩一、加藤善久、遠藤哲也、古賀信幸: 2,3',4,5,5'-Pentachlorobiphenyl (CB120)とその予想代謝物の合成 中村学園大学・中村学園大学短期大学部研究紀要、42、333-338 (2010)
2009
Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Yoshiki Seto, Shin-ichi Ikushiro, Toshiyuki Sakaki, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa: 4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl-mediated decrease in serum thyroxine level in mice occurs through increase in accumulation of thyroxine in the liver. Drug Metab. Dispos., 37, 2095-2102 (2009)
Yoshihisa Kato, Syohei Okada, Kazutaka Atobe, Tetsuya Endo, Futoshi Matsubara, Takayoshi Oguma and Koichi Haraguchi: Simultaneous determination by APCI-LC/MS/MS of hydroxylated and methoxylated polybrominated diphenyl ethers found in marine biota. Anal. Chem., 81, 5942-5948 (2009)
Tetsuya Endo, Yohsuke Hisamichi, Osamu Kimura, Yuichi Kotaki, Yoshihisa Kato, Chiho Ohta, Nobuyuki Koga and Koichi Haraguchi: Contamination levels of mercury in the muscle of female and male spiny dogfishes (Squalus acanthias) caught off the coast of Japan. Chemosphere, 77, 1333-1337 (2009)
Takashi Okura, Tadahiro Ozawa, Michiko Ibe, Yuko Taki, Midori Kimura, Yoshiyuki Kagawa, Yoshihisa Kato and Shizuo Yamada: Effects of repeated morphine treatment on the antinociceptive effects, intestinal absorption, and efflux from intestinal epithelial cells of morphine. Biol. Pharm. Bull., 32, 1571-1575 (2009)
Koichi Haraguchi, Akio Koizumi, Kayoko Inoue, Kouji H. Harada, Toshiaki Hitomi, Mutsuko Minata, Miyako Tanabe, Yoshihisa Kato, Eri Nishimura, Yoshiaki Yamamoto, Takao Watanabe, Katsunobu Takenaka, Shigeki Uehara, Hye-Ran Yang, Min-Young Kim, Chan-Seok Moon, Hae-Sook Kim, Peiyu Wang, Aiping Liu and Nguyen Ngoc Hung: Levels and regional trends of persistent organochlorines and polybrominated diphenyl ethers in Asian breast milk demonstrate POPs signatures unique to individual countries. Environ. Int., 35, 1072-1079 (2009)
Koichi Haraguchi, Yohsuke Hisamichi, Yuichi Kotaki, Yoshihisa Kato and Tetsuya Endo: Halogenated bipyrroles and methoxylated tetrabromodiphenyl ethers in tiger shark (Galeocerdo cuvier) from the southern coast of Japan. Environ. Sci. Technol., 43, 2288-2294 (2009)
太田千穂、原口浩一、加藤善久、遠藤哲也、古賀信幸： 2,2',5,5'-四塩素化ビフェニル(CB52)のウサギ肝ミクロゾームによる代謝. 福岡医学雑誌、100、200-209 (2009)
Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Shin-ichi Ikushiro, Toshiyuki Sakaki, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa : A possible mechanism for the decrease in serum thyroxine level by TCDD-like PCB, 3,3',4,4',5-pentachlorobiphenyl in mice. Organohalogen Compd., 71, 119-122 (2009)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo and Nobuyuki Koga : Metabolism of 2,2',3,4',5',6-hexachlorobiphenyl (CB149) by liver microsomes from rats, hamsters, guinea pigs and humans. Organohalogen Compd., 71, 308-311 (2009)
太田千穂、枩岡樹子、太田英明、加藤善久、古賀信幸: 植物成分diosmetinおよびhesperetinのラット肝ミクロゾームによるin vitro代謝 中村学園大学・中村学園大学短期大学部研究紀要、41、247-254 (2009)
2008
Yoshihisa Kato, Shin-ichi Ikushiro, Yoshikazu Emi, Sekihiro Tamaki, Hiroshi Suzuki, Toshiyuki Sakaki, Shizuo Yamada and Masakuni Degawa: Hepatic UDP-glucuronosyltransferases responsible for glucuronidation of thyroxine T4 in humans. Drug Metab. Dispos., 36, 51-55 (2008)
Koichi Haraguchi, Yoshihisa Kato, Kazutaka Atobe, Syohei Okada, Tetsuya Endo, Futoshi Matsubara and Takayoshi Oguma: Negative APCI-LC/MS/MS method for determination of natural persistent halogenated products in marine biota. Anal. Chem., 80, 9748-9755 (2008)
Tetsuya Endo, Yohsuke Hisamichi, Koichi Haraguchi, Yoshihisa Kato, Chiho Ohta and Nobuyuki Koga: Hg, Zn and Cu levels in the muscle and liver of tiger sharks (Galeocerdo cuvier) from the coast of Ishigaki Island, Japan: Relationship between metal concentrations and body length. Mar. Pollut. Bull., 56, 1774-1780 (2008)
Aiko Kageyama, Tomomi Fujino, Yuko Taki, Yoshihisa Kato, Yoshihisa Nozawa, Yoshihiko Ito and Shizuo Yamada: Alteration of muscarinic and purinergic receptors in urinary bladder of rats with cyclophosphamide-induced interstitial cystitis. Neuroscience Letters, 436, 81-84 (2008)
Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Shin-ichi Ikushiro, Toshiyuki Sakaki, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa: A possible mechanism for the decrease in serum thyroxine level by 4-OH-2,2',3,4',5,5',6-heptachlorobiphenyl in mice. Organohalogen Compd., 70, 1601-1604 (2008)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Mikiko Matsuoka and Nobuyuki Koga : Metabolism of 2,2',3,4',5,5'-hexachlorobiphenyl (CB146) by liver microsomes from rats, hamsters and guinea pigs. Organohalogen Compd., 70, 1185-1188 (2008)
Nobuyuki Koga, Chiho Ohta, Koichi Haraguchi, Mikiko Matsuoka, Yoshihisa Kato and Tetsuya Endo: The formation of a catechol metabolite of 2,2',4,5,5'-pentachlorobiphenyl (CB101) by liver microsomes from rats, hamsters, guinea pigs and humans. Persistent Organic Pollutants (POPs) Research in Asia, Edited by Masatoshi Morita, pp.292-297, DIOXIN2007 International symposium organizing committee (2008)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Mikiko Matsuoka, Tetsuya Endo and Nobuyuki Koga: The distribution of metabolites of 2,2',3,4,4',5',6-heptachlorobiphenyl (CB183) in rats and guinea pigs. Persistent Organic Pollutants (POPs) Research in Asia, Edited by Masatoshi Morita, pp.236-241, DIOXIN2007 International symposium organizing committee (2008)
2007
Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa: A novel mechanism for polychlorinated biphenyl-induced decrease in serum thyroxine level in rats. Drug Metab. Dispos., 35, 1949-1955 (2007)
Yoshikazu Emi, Shin-ichi Ikushiro and Yoshihisa Kato: Thyroxine-metabolizing rat UDP-glucuronosyltransferase 1A7 is regulated by thyroid hormone receptor. Endocrinology, 148, 6124-6133 (2007)
Nobuyuki Koga, Miki Matsuo, Chiho Ohta, Koichi Haraguchi, Mikiko Matsuoka, Yoshihisa Kato, Toshinao Ishii, Masamichi Yano and Hideaki Ohta: Comparative study on nobiletin metabolism with liver microsomes from rats, guinea pigs and hamsters and rat cytochrome P450. Biol. Pharm. Bull., 30, 2317-2323 (2007)
Shinya Uchida, Souhei Kurosawa, Tomomi Fujino (Oki), Yoshihisa Kato, Masato Nanri, Kenichiro Yoshida and Shizuo Yamada: Binding activities by propiverine and its N-oxide metabolites of L-type calcium channel antagonist receptors in the rat bladder and brain. Life Sci., 80, 2454-2460 (2007)
太田千穂、枩岡樹子、原口浩一、加藤善久、遠藤哲也、古賀信幸: 2,2',4,5,5'-五塩素化ビフェニル(CB101)のラット、ハムスターおよびモルモット肝ミクロゾームによる代謝. 福岡医学雑誌、98、236-244 (2007)
Nobuyuki Koga, Chiho Ohta, Koichi Haraguchi, Mikiko Matsuoka, Yoshihisa Kato and Tetsuya Endo: The formation of a catechol metabolite of 2,2',4,5,5'-pentachlorobiphenyl (CB101) by liver microsomes from rats, hamsters, guinea pigs and humans. Organohalogen Compd., 69, 1757-1760 (2007)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Mikiko Matsuoka, Tetsuya Endo and Nobuyuki Koga : The distribution of metabolites of 2,2',3,4,4',5',6-heptachlorobiphenyl (CB183) in rats and guinea pigs. Organohalogen Compd., 69, 1761-1764 (2007)
2006
Shin-ichi Ikushiro, Yoshikazu Emi, Yoshihisha Kato, Shizuo Yamada and Toshiyuki Sakaki: Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isozymes. Drug Metab. Pharmacokinet., 21, 70-74 (2006)
Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Sekihiro Tamaki, Koichi Haraguchi, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno and Masakuni Degawa : A possible mechanism for the decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats. Organohalogen Compd., 68, 1442-1445 (2006)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Ozaki Mari and Nobuyuki Koga : In vitro metabolism of 2,2',3,4,4',5',6-heptachlorobiphenyl (CB183) with liver microsomes from rats, guinea pigs and hamsters. Organohalogen Compd., 68, 1733-1736 (2006)
2005
Yoshihisa Kato, Hiroshi Suzuki, Shinichi Ikushiro, Shizuo Yamada and Masakuni Degawa: Decrease in serum thyroxine level by phenobarbital in rats is not necessarily dependent on increase in hepatic UDP-glucuronosyltransferase. Drug Metab. Dispos., 33, 1608-1612 (2005)
Yoshihisa Kato, Koichi Haraguchi, Tomoaki Yamazaki, Ryohei Kimura, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa: The decrease in level of serum thyroxine by 2,2',4,5,5'-pentachlorobiphenyl in rats and mice: No correlation with formation of methylsulfonyl metabolites. Drug Metab. Dispos., 33, 1661-1665 (2005)
Koichi Haraguchi, Yoshihisa Kato, Nobuyuki Koga and Masakuni Degawa: Species differences in the tissue distribution of catechol and methylsulphonyl metabolites of 2,4,5,2',5'-penta- and 2,3,4,2',3',6'-hexachlorobiphenyls in rats, mice, hamsters and guinea pigs. Xenobiotica, 35, 85-96 (2005)
Koichi Haraguchi, Nobuyuki Koga and Yoshihisa Kato: Comparative metabolism of polychlorinated biphenyls and tissue distribution of persistent metabolites in rats, hamsters, and guinea pigs. Drug Metab. Dispos., 33, 373-380 (2005)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato and Nobuyuki Koga: In vitro metabolism of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) by liver microsomes from rats, hamsters and guinea pigs. Xenobiotica, 35, 319-330 (2005)
加藤善久: 甲状腺ホルモン撹乱物質の生体作用の動物種差．生体統御システムと内分泌撹乱．井上 達、井口泰泉編、pp.123-129、シュプリンガー・フェアラーク東京 (2005)
太田千穂、原口浩一、加藤善久、古賀信幸：2,3',4,4',5-五塩素化ビフェニル（CB118）のモルモット肝ミクロゾームによる代謝．福岡医学雑誌、96、232-240 (2005)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato and Nobuyuki Koga: In vivo metabolism of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) in guinea pigs. Organohalogen Compd., 67, 2343-2345 (2005)
2004
Yoshihisa Kato, Shinichi Ikushiro, Koichi Haraguchi, Tomoaki Yamazaki, Yuriko Ito, Hiroshi Suzuki, Ryohei Kimura, Shizuo Yamada, Tohru Inoue and Masakuni Degawa: A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats. Toxicol. Sci., 81, 309-315 (2004)
Kelly J. Gauger, Yoshihisa Kato, Koichi Haraguchi, Hans-Joachim Lehmler, Larry W. Robertson, Ruby Bansal and R. Thomas Zoeller: Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors. Environ. Health Perspect., 112, 516-523 (2004)
Koichi Haraguchi, Yoshihisa Kato, Nobuyuki Koga and Masakuni Degawa: Metabolism of polychlorinated biphenyls by Gunn rats: Identification and serum retention of catechol metabolites. Chem. Res. Toxicol., 17, 1684-1691 (2004)
加藤善久、木村良平、山田静雄、出川雅邦：PCB類による甲状腺ホルモンかく乱作用とその作用機構：動物種差．環境変異原研究、26、101-106 (2004)
加藤善久、山田静雄、出川雅邦：Polychlorinated biphenylsによる血中サイロキシン濃度低下作用機構． Endocrine Disrupter News Letter, 7, 2 (2004)
Nobuyuki Koga, Chiho Ohta, Koichi Haraguchi, Tomoyo Kanamaru, Yoshihisa Kato and Shizuo Yamada: In vitro metabolism of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) with liver microsomes of rats, hamsters and guinea pigs. Organohalogen Compd., 66, 2882-2886 (2004)
榊原紀和 博士（薬学）、薬剤師
私はこれまで、生理活性物質の有機合成的手法を用いた創薬、あるいは生理活性物質の植物内での代謝フローの解明に関する研究に従事して参りました。香川薬学部薬物動態学講座では、それらを研究基盤として薬物動態学あるいは薬物代謝学の研究に発展させたいと考えております。さらに、本学部薬事科学講座の丸山徳見教授らによって見出された低分子初の血管新生促進剤、COA-Clの構造活性相関について解析し、LC/MS/MSを用いて本化合物の生体内動態についての研究を推し進めたいと考えております。
教育に関しては、香川薬学部の学生達を「薬学共用試験CBT」および「薬剤師国家試験」に合格させるよう最大限努力するとともに、就職後、薬剤師として現場で役立つ講義を推進したいと考えています。とりわけ私が当講座の加藤善久教授と共に担当する「薬剤学」や「薬物動態学」は、薬学部でのみ学ぶことの出来る科目です。それらの科目の習得は、卒業後、薬剤師として働く上で直接役立つ必要不可欠な知識や技能となります。今後、香川薬学部の学生達が、講義で培った知識に加えて、薬局・病院実習において知識、技能、態度を習得し、卒業後は真に社会に貢献出来る薬剤師として活躍出来るよう、精一杯の教育活動を行っていく所存であります。
日本薬学会、日本薬剤学会、日本ケミカルバイオロジー学会、抗ウイルス療法研究会、日本化学会、有機合成化学協会
2013
Norikazu Sakakibara, Takayuki Hamasaki, Masanori Baba, Yosuke Demizu, Masaaki Kurihara, Kohji Irie, Masatoshi Iwai, Eriko Asada, Yoshihisa Kato, and Tokumi Maruyama: Synthesis and evaluation of novel 3-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents. Bioorg. Med. Chem., (2013) 21, 5900-5906.
Norikazu Sakakibara, Ikuko Tsukamoto, Yohei Isono, Maki Takata, Ryoji Konishi, Yoshihisa Kato, and Tokumi Maruyama: A new method for synthesis and angiogenic evaluation of leteprinim potassium and its novel analogs. Heterocycles, (2013) 87, 2369-2384.
Toshiaki Umezawa, Safendrri Komara Ragamustari, Tomoyuki Nakatsubo, Shohei Wada, Laigeng Li, Masaomi Yamamura, Norikazu Sakakibara, Takefumi Hattori, Shiro Suzuki, and Vincent L. Chiang: A lignan O-methyltransferase catalyzing the regioselective methylation of matairesinol in Carthamus tinctorius. Plant Biotechnology, (2013) 30, 97-109.
Naohiko Okabe, Emi Nakamura, Naoyuki Himi, Kazuhiko Narita, Ikuko Tsukamoto, Tokumi Maruyama, Norikazu Sakakibara, Takehiro Nakamura, Toshifumi Itano, and Osamu Miyamoto: Delayed administration of the nucleic acid analog 2Cl-C.OXT-A attenuates brain damage and enhances functional recovery after ischemic stroke. Brain Research, (2013) 1506, 115-131.
榊原紀和、丸山徳見、加藤善久：血管新生促進作用および抗HIV-1作用を有する新規核酸類縁体の創製. 香川県薬剤師会会誌 かがやく、(2013) 150, 68-70.
2012
Norikazu Sakakibara, Ikuko Tsukamoto, Takashi Tsurura, Maki Takata, Ryoji Konishi, and Tokumi Maruyama: Novel synthesis of carbocyclic oxetanocin analogs (2-Alkoxy-C.OXT-A) and their tube formation activities of human umbilical vein endothelial cells (HUVEC). Heterocycles, 85, 1105-1116（2012）.
Paula Ordonez, Takayuki Hamasaki, Yohei Isono, Norikazu Sakakibara, Masahiro Ikejiri, Tokumi Maruyama, and Masanori Baba: Anti-human immunodeficiency virus type 1 activity of novel 6-substituted 1-benzyl-3-(3,5-dimethylbenzyl)uracil derivatives. Antimicrob. Agents Chemother., 56, 2581-2589 (2012)
Norikazu Sakakibara, Ai Kakoh, and Tokumi Maruyama: First synthesis of [6-15N]-cladribine using ribonucleoside as a starting material. Heterocycles, 85, 171-182 (2012)
2011
Norikazu Sakakibara, Masahiro Komatsu, and Tokumi Maruyama: One-pot synthesis of 2-nitrooxyalkoxylated inosine analogs using cyclic ether and isoamyl nitrite. Heterocycles, 83, 2865-2872 (2011)
Norikazu Sakakibara, Takashi Tsuruta, Masahiro Komatsu, Masatoshi Iwai, and Tokumi Maruyama: A new method for synthesis of 2-alkoxyadenosine analogs. Heterocycles, 83, 2299-2311 (2011)
Yohei Isono, Norikazu Sakakibara, Paula Ordonez, Takayuki Hamasaki, Masanori Baba, Masahiro Ikejiri, and Tokumi Maruyama: Synthesis of 1-benzyl-3-(3,5-dimethylbenzyl) uracil derivatives with potential anti-HIV activity. Antiviral Chemistry & Chemotherapy, 22, 57-65 (2011)
Masaomi Yamamura, Shohei Wada, Norikazu Sakakibara, Tomoyuki Nakatsubo, Shiro Suzuki, Takefumi Hattori, Migiwa Takeda, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, and Toshiaki Umezawa: Occurrence of guaiacyl/p-hydroxyphenyl lignin in arabidopsis thaliana T87 cells. Plant Biotechnology, 28, 1-8 (2011)
2010
Ikuko Tsukamoto, Norikazu Sakakibara, Tokumi Maruyama, Junsuke Igarashi, Hiroaki Kosaka, Yasuo Kubota, Masaaki Tokuda, Hiromi Ashino, Kenichi Hattori, Shinji Tanaka, Mitsuhiro Kawata, and Ryoji Konishi: A novel nucleic acid analogue shows strong angiogenic activity. Biochem. Biophysi. Res. Commun., 399, 699-704 (2010)
Shiro Suzuki, Norikazu Sakakibara, Laigeng Li, Toshiaki Umezawa, and Vincent L. Chiang: Profiling of phenylpropanoid monomers in developing xylem tissue of transgenic aspen (Populus tremuloides). J. Wood Sci., 56, 71-76 (2010)
2008
Tomoyuki Nakatsubo, Yu Kitamura, Norikazu Sakakibara, Masaharu Mizutani, Takefumi Hattori, Nozomu Sakurai, Daisuke Shibata, Shiro Suzuki, and Toshiaki Umezawa: At5g54160 gene encodes arabidopsis thaliana 5-hydroxyconiferaldehyde o-methyltransferase. J. Wood Sci., 54, 312-317 (2008)
跡部一孝 博士（薬学）、薬剤師
準備中
日本薬学会、日本DDS学会、日本薬剤学会
準備中
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